Anti-ulcer Effects of Chitin and Chitosan, Healthy Foods, in Rats

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Author(s)

Abstract

In this study, we compared the effects of low molecular weight(LMW)chitosan(MW:25, 000-50, 000), high molecular weight(HMW)chitosan(MW:500, 000-1000, 000)and chitin on ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats.Oral administration of LMW chitosan(250, 500 and 1000mg/kg)dose-dependently prevented ethanol-induced gastric mucosal injury.Repeated oral administration of LMW chitosan(100, 200 and 400mg/kg twice daily)also dose-dependently accelerated the gastric ulcer healing.However, the effects of HMW chitosan and chitin on the gastric mucosal injury formation and the gastric ulcer healing were less potent than those of LMW chitosan.LMW chirosan(250 and 500mg/kg, orally)was ineffective in inhibiting gastric acid secretion in pylorus-ligated rats, although it had a weak acid-neutralizing action.LMW-chitosan(250, 500 and 1000mg/kg orally)dose-dependently prevented the decrease in gastric mucus content induced by ethanol.These results indicate that of the three compounds, LMW chitosan has the most potent gastric cytoprotective and ulcer healing-promoting actions.In addition, gastric mucus-increasing action of LMW-chitosan may be, at least in part, related to the anti-ulcer effect of this compound.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(3), 218-225, 2000-03-01

    The Japanese Pharmacological Society

References:  18

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008183494
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5321012
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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