Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats

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Author(s)

Abstract

The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO), a nitric oxide(NO)scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously.Lipopolysaccharide(LPS)(10mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance.Administration of carboxy-PTIO(1.7mg·kg<SUP>-1</SUP>·min<SUP>-1</SUP>, i.v.for 60min) at 90min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance.It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(3), 261-264, 2000-03-01

    The Japanese Pharmacological Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008183637
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5321099
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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