Metabolic Abnormalities Caused by 3-Acetylpyridine in the Cerebral Motor Regions of Rats: Partial Recovery by Thyrotropin-Releasing Hormone

Access this Article

Author(s)

Abstract

Although 3-acetylpyridine(3-AP) induces several motor disturbances and it degenerates the olivocerebellar pathway, abnormalities caused by 3-AP in cerebral motor regions remain to be elucidated.Here we investigated the metabolic changes caused by 3-AP(75mg/kg, i.p.) on local cerebral glucose utilization(LCGU) in various brain regions.The effects of anti-ataxic agents, thyrotropin-releasing hormone(TRH)(10mg/kg, i.p.) and its mimetic agent taltirelin hydrate(1mg/kg, i.p.), on the 3-AP-induced change in LCGU were also investigated.The LCGU in the nuclei of the basal ganglia, thalamus, limbic structures and brainstem of 3-AP-treated rats was significantly lower than that of naive animals.However 3-AP increased the LCGU of the cerebellar nuclei.TRH restored depressed LCGU in the substantia nigra and ventral tegmental area.TRH tended to restore the lowered LCGU in several nuclei of 3-AP-treated rats.Moreover, taltirelin further increased the LCGU in the cerebellar nuclei.These results suggest that the motor disturbance of the 3-AP-treated rats may be due to not only degeneration of the olivocerebellar pathway but also dysfunction of the several areas that play a role in motor coordination.Moreover, the anti-ataxic action by TRH could result from metabolic restoration of the multiple motor-coordination-related areas.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(4), 295-300, 2000-04-01

    The Japanese Pharmacological Society

References:  28

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008183803
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5362719
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top