Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System

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Author(s)

Abstract

Recent studies have indicated that sphingosine 1-phosphate(Sph-1-P)is released into the blood flow from activated platelets upon stimulation to exhibit a wide spectrum of biological functions.The purpose of the present study was to assess the acute cardiovascular effects of circulating Sph-1-P in the in vivo rat model.Intravenous administration of Sph-1-P decreased the heart rate, ventricular contraction and blood pressure, while it hardly affected the atrioventricular and intraventricular conduction.Sph-1-P did not affect the adenylate cyclase activities of the membrane preparations made from the right atrium and left ventricle.These results suggest that functional receptors like lysophospholipid receptor Edg-1, which can inhibit adenylate cyclase via G<SUB>i</SUB> protein, are lacking in the rat heart.Moreover, these observations will provide a clue to better understand the various types of Sph-1-P-related pathophysiological processes.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(4), 338-342, 2000-04-01

    The Japanese Pharmacological Society

References:  16

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008183986
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5362816
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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