Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the cardiovascular system

• Sugiyama Atsushi

  Department of Pharmacology, Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan

• Nu Aye Nu

  Department of Pharmacology, Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan

• Yatomi Yutaka

  Department of Laboratory Medicine,Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan

• Ozaki Yukio

  Department of Laboratory Medicine,Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan

• Hashimoto Keitaro

  Department of Pharmacology, Yamanashi Medical University Tamaho-cho,Nakakoma-gun,Yamanashi 409-3898,Japan

書誌事項

タイトル別名

• Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System.

抄録

Recent studies have indicated that sphingosine 1-phosphate(Sph-1-P)is released into the blood flow from activated platelets upon stimulation to exhibit a wide spectrum of biological functions.The purpose of the present study was to assess the acute cardiovascular effects of circulating Sph-1-P in the in vivo rat model.Intravenous administration of Sph-1-P decreased the heart rate, ventricular contraction and blood pressure, while it hardly affected the atrioventricular and intraventricular conduction.Sph-1-P did not affect the adenylate cyclase activities of the membrane preparations made from the right atrium and left ventricle.These results suggest that functional receptors like lysophospholipid receptor Edg-1, which can inhibit adenylate cyclase via G_i protein, are lacking in the rat heart.Moreover, these observations will provide a clue to better understand the various types of Sph-1-P-related pathophysiological processes.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 82 (4), 338-342, 2000

  公益社団法人 日本薬理学会

キーワード

• Sphingosine 1-phosphate
• Heart rate
• Blood pressure
• Contraction
• Adenylate cyclase

詳細情報

• CRID: 1390001204287736448
• NII論文ID: 10008183986
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.82.338
• COI: 1:CAS:528:DC%2BD3cXisl2gsLk%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 5362816
• PubMed: 10875754
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5362816
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819306717?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819306717?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/82/4/82_4_338/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000188500
• 本文言語コード: en
• データソース種別:
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