Possible Role of Potassium Channels in Mu-receptor-Mediated Inhibition and Muscarinic Autoinhibition in Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum

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著者

    • Saitoh Noriko SAITOH Noriko
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • TAKEUCHI Tadayoshi
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • HATA Fumiaki
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University

抄録

It is known that mu-agonists inhibit electrical field stimulation(EFS)-evoked ACh release from longitudinal muscle myenteric plexus(LMMP)preparation of guinea pig ileum when muscarinic autoinhibition does not fully work.In the present study, the possible role of K<SUP>+</SUP> channels in the mechanisms of mu-agonists-induced inhibition and autoinhibition of ACh release was studied.In the presence of atropine, which blocks the autoinhibition, non-selective K<SUP>+</SUP> channel blockers, tetraethylammonium(TEA)and 4-amino-pyridine(4-AP), reversed the inhibitory effect of mu-agonists, morphine and [D-Ala<SUP>2</SUP>, N-Me-Phe<SUP>4</SUP>, Gly<SUP>5</SUP>-ol]enkephalin, on EFS-evoked ACh release, but not that of kappa-agonist U-50, 488.Apamin, iberiotoxin or glibenclamide did not affect the inhibition of ACh release by morphine.On the other hand, in the absence of atropine(under the autoinhibition working condition), 4-AP increased EFS-evoked ACh release, but atropine did not further increase ACh release in the presence of 4-AP.In contrast, although TEA did not affect EFS-evoked ACh release, atropine increased ACh release in the presence of TEA.These results suggest that the inhibitory effects of mu-agonists and muscarinic autoinhibition on the ACh release are associated with activation of different types of K<SUP>+</SUP> channels in the guinea pig LMMP preparations:the former is associated with 4-AP- and TEA-sensitive K<SUP>+</SUP> channels and the latter is associated with 4-AP- but not TEA-sensitive K<SUP>+</SUP> channels.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(4), 343-349, 2000-04-01

    公益社団法人 日本薬理学会

参考文献:  36件中 1-36件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008184003
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5362824
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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