Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Fecal Pellet Output Induced by Hyperpropulsion in Gastrointestine of Rats

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Author(s)

Abstract

The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug.5-Hydroxytryptamine(10mg/kg, s.c.), neostigmine(0.3mg/kg, s.c.)and nicotine(1.0mg/kg, s.c.)increased fecal pellet output.Zaldaride(≥30mg/kg, p.o.)reduced these increases in facal pellet outputs.Loperamide(10mg/kg, p.o.)inhibited fecal pellet output induced by 5-hydroxytryptamine and neostigmine but not nicotine.Under normal conditions, zaldaride and loperamide did not affect fecal pellet output at doses used in these studies.In conclusion, zaldaride may inhibit increases in fecal pellet output induced by hyperpropulsion of the gastrointestinal tract without causing constipation as a side effect.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(4), 350-352, 2000-04-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008184040
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5362831
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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