Contribution of NMDA Receptors to Activity of Augmenting Epiratory Neurons in Vagotomized Cats

DOI Web Site Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 参考文献29件
  • Haji Akira
    Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
  • Okazaki Mari
    Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
  • Takeda Ryuji
    Department of Pharmacology,Faculty of Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan

書誌事項

タイトル別名
  • Contribution of NMDA Receptors to Activity of Augmenting Expiratory Neurons in Vagotomized Cats.

この論文をさがす

抄録

To identify the NMDA receptor-mediated mechanism in augmenting expiratory(E2)neurons, the effects of systemic and local application of dizocilpine on spontaneous and evoked postsynaptic potentials(PSPs)were investigated in decerebrate and vagotomized cats.Intravenously applied dizocilpine reduced the inhibitory PSPs during inspiration and stage 1 expiration, but had little effect on the excitatory PSPs during stage 2 expiration.Iontophoresed dizocilpine caused a continuous hyperpolarization throughout the respiratory cycle.Dizocilpine had no effect on vagally evoked PSPs.These results suggest that the NMDA mechanisms are involved presynaptically in periodic postsynaptic inhibitions and postsynaptically in tonic excitation in E2 neurons.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 82 (4), 353-357, 2000

    公益社団法人 日本薬理学会

参考文献 (29)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ