Drug-Induced Torsado de Pointes: From Molecular Biology to Bedside

• Tamargo Juan

  Department of Pharmacology,School of Medicine,Universidad Complutense,28040 Madrid,Spain

書誌事項

タイトル別名

• Drug-Induced Torsade de Pointes. From Molecular Biology to Bedside.
• Drug-induced torsades de pointes: from molecular biology to bedside

抄録

A progressively increasing number of cardiac and noncardiac drugs prolong the ventricular action potential duration(QT interval of the electrocardiogram)and cause a distinctive polymorphic ventricular tachycardia termed torsades de pointes(TdP)that can degenerate into ventricular fibrillation and sudden cardiac death.Drugs prolong the QT interval and cause TdP by blocking cardiac K⁺ channels in general and selectively blocking the rapidly activating delayed rectifier channel I_Kr.Coassembly of HERG(human−ether−ago−go−related gene)α−subunits and MiRP1(MinK−related peptide 1)β−subunits recapitulate the behavior of native human I_Kr and mutations of HERG and MiRP1 decrease the repolarizing current, delay ventricular repolarization and prolong the QT.Thus, drug−induced QT prolongation and TdP might represent an iatrogenic reproduction of the congenital LQTS.In patients with silent forms of the congenital LQTS associated with mutations in I_Kr, arrhythmic symptoms developed almost exclusively after exposure to QT−prolonging drugs.This review centers on the possible cellular mechanisms underlying drug−induced QT prolongation and TdP, the description of specific drugs and risk factors facilitating the development of TdP, and the recommendations for preventing and treating this potentially fatal arrhythmia.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 83 (1), 1-19, 2000

  公益社団法人 日本薬理学会

キーワード

• Potassium channel
• HERG(human-ether-a-go-go-related gene)
• MiRP1(MinK-related peptide 1)
• Long QT syndrome
• Cardiac arrhythmia
• Torsade de pointes

詳細情報

• CRID: 1390282679262183680
• NII論文ID: 10008184072
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.83.1
• COI: 1:CAS:528:DC%2BD3cXjs12jurc%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 5399678
• PubMed: 10887935
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5399678
• Web Site: https://www.jstage.jst.go.jp/article/jjp/83/1/83_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000255171
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可