Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M_1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice

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Author(s)

Abstract

We previously reported that paeoniflorin but not albiflorin, components of peony root, produced ameliorative effects on scopolamine−induced spatial cognitive impairment in rats.In this study, we examined the effects of paeoniflorin and muscarinic receptor antagonists on long−term potentiation(LTP)of population spike recorded from the CA1 region of rat hippocampal slices.Bath applications of an M<SUB>1</SUB>− and M<SUB>2</SUB>−receptor antagonist scopolamine and a selective M<SUB>1</SUB>−receptor antagonist pirenzepine, at a concentration of 10 μM, significantly suppressed LTP, whereas AF−DX116, a selective M<SUB>2</SUB>−receptor antagonist, failed to affect it.Paeoniflorin(0.1−1μM), which alone was ineffective on LTP induction, significantly reversed the suppressive effects of scopolamine and pirenzepine(10μM).In contrast, albiflorin(0.1−1μM)had no effect on the scopolamine−induced LTP suppression.These results suggest that paeoniflorin reversal of the muscarinic M<SUB>1</SUB>−receptor−mediated inhibition of LTP may be implicated in the ameliorative effect of paeoniflorin on spatial cognitive impairment caused by cholinergic dysfunction.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(1), 25-30, 2000-05-01

    The Japanese Pharmacological Society

References:  19

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008184273
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5399689
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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