Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice.
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- Tabata Keiichi
- Department of Pharmacology,Institute of Natural Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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- Matsumoto Kinzo
- Department of Pharmacology,Institute of Natural Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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- Watanabe Hiroshi
- Department of Pharmacology,Institute of Natural Medicine,Toyama Medical and Pharmaceutical University,2630 Sugitani,Toyama 930-0194,Japan
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We previously reported that paeoniflorin but not albiflorin, components of peony root, produced ameliorative effects on scopolamine−induced spatial cognitive impairment in rats.In this study, we examined the effects of paeoniflorin and muscarinic receptor antagonists on long−term potentiation(LTP)of population spike recorded from the CA1 region of rat hippocampal slices.Bath applications of an M1− and M2−receptor antagonist scopolamine and a selective M1−receptor antagonist pirenzepine, at a concentration of 10 μM, significantly suppressed LTP, whereas AF−DX116, a selective M2−receptor antagonist, failed to affect it.Paeoniflorin(0.1−1μM), which alone was ineffective on LTP induction, significantly reversed the suppressive effects of scopolamine and pirenzepine(10μM).In contrast, albiflorin(0.1−1μM)had no effect on the scopolamine−induced LTP suppression.These results suggest that paeoniflorin reversal of the muscarinic M1−receptor−mediated inhibition of LTP may be implicated in the ameliorative effect of paeoniflorin on spatial cognitive impairment caused by cholinergic dysfunction.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 83 (1), 25-30, 2000
公益社団法人 日本薬理学会
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詳細情報
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- CRID
- 1390001204285468928
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- NII論文ID
- 10008184273
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXjs12ju78%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5399689
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- PubMed
- 10887937
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
- CiNii Articles
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- 使用不可