Decrease of Sexual Receptivity by Prolylendopeptidase Inhibitor in Female Rats

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Author(s)

Abstract

The effects of a prolylendopeptidase inhibitor, 1−[3−(2−indanylanylacetyl)−L−thioprolyl]pyrrolidine(Z−321), on lordosis behavior were investigated in estrogen and progestrone−treated ovariectomized rats.Females were orally administered 100, 200 or 300 mg/kg Z−321 or the vehicle(control).The mean lordosis quotient in the rats given 300 mg/kg Z−321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z−321 was not lower.Thus, Z−321 suppressed lordosis in estrogen and progesterone−treated ovariectomized rats.Peptide neurotransmitters, especially those containing proline, are though to be involved in the inhibitory mechanisms for lordosis behavior.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(1), 82-85, 2000-05-01

    The Japanese Pharmacological Society

References:  17

Codes

  • NII Article ID (NAID)
    10008184471
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5399729
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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