Decrease of Sexual Receptivity by Prolylendiopeptidase Inhibitor in Female Rats

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  • Oosuka Izumi
    Laboratory of Neuroendocrinology,Department of Basic Human Sciences,School of Human Sciences,Waseda University,2-579-15,Mikajima,Tokorozawa,Saitama 359-1192,Japan
  • Tanaka Yoshiaki
    Central Research Laboratories,Zeria Pharmaceutical Co.,Ltd.,2512-1,Oshikiri,Konan-machi,Osato-gun,Saitama 360-0111,Japan
  • Miura Naoyoshi
    Central Research Laboratories,Zeria Pharmaceutical Co.,Ltd.,2512-1,Oshikiri,Konan-machi,Osato-gun,Saitama 360-0111,Japan
  • Yamanouchi Korehito
    Laboratory of Neuroendocrinology,Department of Basic Human Sciences,School of Human Sciences,Waseda University,2-579-15,Mikajima,Tokorozawa,Saitama 359-1192,Japan

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タイトル別名
  • Decrease of Sexual Receptivity by Prolylendopeptidase Inhibitor in Female Rats.

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抄録

The effects of a prolylendopeptidase inhibitor, 1−[3−(2−indanylanylacetyl)−L−thioprolyl]pyrrolidine(Z−321), on lordosis behavior were investigated in estrogen and progestrone−treated ovariectomized rats.Females were orally administered 100, 200 or 300 mg/kg Z−321 or the vehicle(control).The mean lordosis quotient in the rats given 300 mg/kg Z−321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z−321 was not lower.Thus, Z−321 suppressed lordosis in estrogen and progesterone−treated ovariectomized rats.Peptide neurotransmitters, especially those containing proline, are though to be involved in the inhibitory mechanisms for lordosis behavior.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 83 (1), 82-85, 2000

    公益社団法人 日本薬理学会

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