Effects of Zaldaride Maleate, an Antidiarrheal Compound, on Intracellular Ca^<2+>-Mediated Short-Circuit Current Response in the Rat Colonic Mucosa

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Author(s)

Abstract

The effect of zaldaride maleate(ZAL)on intracellular Ca<SUP>2+</SUP>−mediated short−curcuit current(Isc)response in rat colonic mucosa was investigated.The Isc response to acetylcholine was partially reduced by the neuronal blocker tetrodotoxin.The tetrodotoxin−sensitive Isc response to acetylcholine was inhibited by ZAL.The tetrodotoxin−insensitive effect, which indicates direct stimulation of acetylcholine in colonic mucosa, was not affected by ZAL.The Isc response to the Ca<SUP>2+</SUP> ionophore A23187 was reduced by ZAL in the presence of tetrodotoxin.These results suggest that ZAL reduces colonic ion secretion by inhibiting a tetrodotoxin−sensitive neuronal pathway and an intracellular Ca<SUP>2+</SUP> pathway in epithelium.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(1), 86-88, 2000-05-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008184489
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5399734
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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