Roles of Prostanoids Revealed From Studies Using Mice Lacking Specific Prostanoid Receptors

Access this Article

Author(s)

Abstract

The actions of prostanoids in various physiological and pathophysiological conditions have been being examined using mice lacking different prostanoid receptors.Prostaglandin(PG)I<SUB>2</SUB> worked not only as a mediator of inflammation but also as an antithrombotic agent.PGF<SUB>2α</SUB> was found to be an essential inducer of labor.Several important actions of PGE<SUB>2</SUB> are exerted via each of the four PGE<SUB>2</SUB> receptor subtypes:EP<SUB>1</SUB>, EP<SUB>2</SUB>, EP<SUB>3</SUB> and EP<SUB>4</SUB>.PGE<SUB>2</SUB> participated in colon carcinogenesis via the EP<SUB>1</SUB>.PGE<SUB>2</SUB> also participates in ovulation and fertilization and contributes to the control of blood pressure under high−salt intake via the EP<SUB>2</SUB>.PGE<SUB>2</SUB> worked as a mediator of febrile responses to both endogenous and exogenous pyrogens and as a regulator of bicarbonate secretion induced by acid−stimulation in the duodenum via the EP<SUB>3</SUB>.It regulated the closure of ductus arteriosus and showed bone resorbing action via the EP<SUB>4</SUB>.PGD<SUB>2</SUB> was found to be a mediator of allergic asthma.These studies have revealed important roles of prostanoids, some of which had not previously been known.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(4), 279-285, 2000-08-01

    The Japanese Pharmacological Society

References:  61

Cited by:  6

Codes

  • NII Article ID (NAID)
    10008184505
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5501156
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top