Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10

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Author(s)

Abstract

The senescence accelerated mouse(SAM)is known as a murine model of aging.SAM consists of senescence accelerated−prone mouse(SAMP)and senescence accelerated−resistant mouse(SAMR).Previous studies reported that SAMP10 exhibits age−related learning impairments and behavioral depression in a tail suspension test after 7 months.We investigated the changes in emotional behavior in a forced swimming test and in receptors for dopamine and 5−hydroxytryptamine(5−HT)in SAMP10.SAMP10 at 8 months showed an increase of immobility in the test compared with SAMR1.Treatment with desipramine(25 mg/kg, i.p., 3 days)in SAMP10 caused a decrease in immobility.In the cortex from SAMP10, [<SUP>3</SUP>H]quinpirole binding to D<SUB>2</SUB>/D<SUB>3</SUB> dopamine receptors increased significantly compared with control SAMR1.In the hippocampus from SAMP10, [<SUP>3</SUP>H]8−hydroxy DPAT binding to 5−HT<SUB>1A</SUB> receptor increased.In midbrains from SAMP10, bindings of [<SUP>3</SUP>H]quinpirole and [<SUP>3</SUP>H]8−hydroxy DPAT increased.[<SUP>3</SUP>H]SCH23390 binding to D<SUB>1</SUB>/D<SUB>5</SUB> receptors and [<SUP>3</SUP>H]ketanserin binding to 5−HT<SUB>2</SUB> receptor in brain regions examined in SAMP10 were similar to those in SAMR1.The present findings represent the first neurochemical evidence of an increase of D<SUB>2</SUB>/D<SUB>3</SUB> and 5−HT<SUB>1A</SUB> receptors in SAMP10.SAMP10 may be a useful model of aging associated depressive behavior.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(4), 312-318, 2000-08-01

    The Japanese Pharmacological Society

References:  40

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008184678
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5501232
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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