Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxytryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10

• Onodera Takahiro

  Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Hokkaido University,Sapporo 060-0812,Japan

• Watanabe Ritsuko

  Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Hokkaido University,Sapporo 060-0812,Japan

• Kyi Tha Kyi

  Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Hokkaido University,Sapporo 060-0812,Japan Hokkaido Foundation for the Promotion of Scientific and Industrial Technology,Sapporo 060-0001,Japan

• Hayashi Yuka

  Hokkaido Foundation for the Promotion of Scientific and Industrial Technology,Sapporo 060-0001,Japan

• Murayama Toshihiko

  Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Hokkaido University,Sapporo 060-0812,Japan

• Okuma Yasunobu

  Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Hokkaido University,Sapporo 060-0812,Japan

• Ono Chizuko

  New Drug Development Research Center,Inc.,Eniwa 061-1405,Japan

• Oketani Yoneshiro

  New Drug Development Research Center,Inc.,Eniwa 061-1405,Japan

• Hosokawa Masanori

  Department of Senescence Biology,Chest Disease Research Institute,Kyoto University,Kyoto 606-8397,Japan

• Nomura Yasuyuki

  Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Hokkaido University,Sapporo 060-0812,Japan

書誌事項

タイトル別名

• Depressive Behavior and Alterations in Receptors for Dopamine and 5-Hydroxyiryptamine in the Brain of the Senescence Accelerated Mouse (SAM)-P10.

抄録

The senescence accelerated mouse(SAM)is known as a murine model of aging.SAM consists of senescence accelerated−prone mouse(SAMP)and senescence accelerated−resistant mouse(SAMR).Previous studies reported that SAMP10 exhibits age−related learning impairments and behavioral depression in a tail suspension test after 7 months.We investigated the changes in emotional behavior in a forced swimming test and in receptors for dopamine and 5−hydroxytryptamine(5−HT)in SAMP10.SAMP10 at 8 months showed an increase of immobility in the test compared with SAMR1.Treatment with desipramine(25 mg/kg, i.p., 3 days)in SAMP10 caused a decrease in immobility.In the cortex from SAMP10, [³H]quinpirole binding to D₂/D₃ dopamine receptors increased significantly compared with control SAMR1.In the hippocampus from SAMP10, [³H]8−hydroxy DPAT binding to 5−HT_1A receptor increased.In midbrains from SAMP10, bindings of [³H]quinpirole and [³H]8−hydroxy DPAT increased.[³H]SCH23390 binding to D₁/D₅ receptors and [³H]ketanserin binding to 5−HT₂ receptor in brain regions examined in SAMP10 were similar to those in SAMR1.The present findings represent the first neurochemical evidence of an increase of D₂/D₃ and 5−HT_1A receptors in SAMP10.SAMP10 may be a useful model of aging associated depressive behavior.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 83 (4), 312-318, 2000

  公益社団法人 日本薬理学会

キーワード

• Senescence accelerated mouse
• Depression
• Dopamine
• 5-Hydroxytryptamine
• Receptor

詳細情報

• CRID: 1390001204286975488
• NII論文ID: 10008184678
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.83.312
• COI: 1:CAS:528:DC%2BD3cXmtV2ksrk%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 5501232
• PubMed: 11001177
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5501232
• Web Site: https://www.jstage.jst.go.jp/article/jjp/83/4/83_4_312/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001024193
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可