Day/Night Variation of 5-Hydroxyindole Acetic Acid Concentration in Rat Cerebrospinal Fluid After Acute and Long-Term Administration of a Selective Serotonin Reuptake Inhibitor, Fluvoxamine

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Author(s)

Abstract

When 30 mg/kg, p.o.of fluvoxamine, a selective serotonin reuptake inhibitor, was administered, significant increases of 3−methoxy−4−hydroxyphenylglycol(MHPG)and 5−hydroxy indole−3−acetic acid(5−HIAA)contents in rat cerebrospinal fluid(CSF)were observed from two days after administration of fluvoxamine in both the light and dark periods and in the dark period of the light/dark cycle, respectively.In long−term treatment with 15 mg/kg, p.o.of fluvoxamine, the level of MHPG in CSF exhibited no difference, whereas the levels of 5−HIAA showed a significant increase during the light periods.These results suggest that fluvoxamine enhances the 5−HT system, but only with long−term treatment.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(4), 344-347, 2000-08-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008184817
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5501294
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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