Day/Night Variation of 5-Hydroxyindole Acetic Acid Concentration in Rat Cerebrospinal Fluid After Acute and Long-Term Administration of a Selective Serotonin Reuptake Inhibitor, Fluvoxamine.

DOI Web Site Web Site PubMed 27 References
  • Egashira Toru
    Department of Pharmacology,Oita Medical University,1-1,Idaigaoka,Hasama-machi,Oita 879-5593,Japan
  • Takayama Fusako
    Department of Pharmacology,Oita Medical University,1-1,Idaigaoka,Hasama-machi,Oita 879-5593,Japan
  • Yamanaka Yasumitsu
    Department of Pharmacology,Oita Medical University,1-1,Idaigaoka,Hasama-machi,Oita 879-5593,Japan Department of Pharmacology,Tokyo Medical College,6-1-1,Shinjuku,Tokyo 160-8402,Japan
  • Takada Kaori
    Department of Pharmacology,Tokyo Medical College,6-1-1,Shinjuku,Tokyo 160-8402,Japan
  • Takeda Hiroshi
    Department of Pharmacology,Tokyo Medical College,6-1-1,Shinjuku,Tokyo 160-8402,Japan
  • Matsumiya Teruhiko
    Department of Pharmacology,Tokyo Medical College,6-1-1,Shinjuku,Tokyo 160-8402,Japan

Search this article

Abstract

When 30 mg/kg, p.o.of fluvoxamine, a selective serotonin reuptake inhibitor, was administered, significant increases of 3−methoxy−4−hydroxyphenylglycol(MHPG)and 5−hydroxy indole−3−acetic acid(5−HIAA)contents in rat cerebrospinal fluid(CSF)were observed from two days after administration of fluvoxamine in both the light and dark periods and in the dark period of the light/dark cycle, respectively.In long−term treatment with 15 mg/kg, p.o.of fluvoxamine, the level of MHPG in CSF exhibited no difference, whereas the levels of 5−HIAA showed a significant increase during the light periods.These results suggest that fluvoxamine enhances the 5−HT system, but only with long−term treatment.

Journal

References(27)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top