Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria

この論文にアクセスする

この論文をさがす

著者

抄録

We investigated the effects of a continuous infusion of adenosine on responses of sinus rate and developed tension to bolus injections of adenosine and acetylcholine in isolated, blood−perfused canine right atria.Each drug was directly injected into the sinus node artery of the isolated atrium.During adenosine infusions, the negative chronotropic and inotropic responses to bolus injections of adenosine were significantly inhibited in a dose−related manner, while the negative responses to administered acetylcholine were consistently potentiated.These results indicate that adenosine infusion has an acute desensitizing action on subsequent bolus adenosine, although the cholinergic action is enhanced by a continuous infusion of adenosine.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(4), 348-350, 2000-08-01

    公益社団法人 日本薬理学会

参考文献:  9件中 1-9件 を表示

各種コード

  • NII論文ID(NAID)
    10008184833
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5501305
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ