Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria

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Author(s)

Abstract

We investigated the effects of a continuous infusion of adenosine on responses of sinus rate and developed tension to bolus injections of adenosine and acetylcholine in isolated, blood−perfused canine right atria.Each drug was directly injected into the sinus node artery of the isolated atrium.During adenosine infusions, the negative chronotropic and inotropic responses to bolus injections of adenosine were significantly inhibited in a dose−related manner, while the negative responses to administered acetylcholine were consistently potentiated.These results indicate that adenosine infusion has an acute desensitizing action on subsequent bolus adenosine, although the cholinergic action is enhanced by a continuous infusion of adenosine.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(4), 348-350, 2000-08-01

    The Japanese Pharmacological Society

References:  9

Codes

  • NII Article ID (NAID)
    10008184833
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5501305
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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