Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats

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Author(s)

Abstract

The term for re−entrainment to a new light−dark cycle in streptozotocin(STZ)−induced diabetic rats was significantly longer than that in control rats.In STZ−induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application.Therefore, 5−HT function in the hypothalamus is thought to be decreased in STZ−induced diabetic rats.These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ−induced diabetic rats.Therefore, 5−HT mechanisms may play an important role in the maintenance of this function.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 83(4), 355-358, 2000-08-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008184858
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5501326
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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