Food Deprivation Depletes Gastric Mucus Glycoprotein in Streptozotocin-Induced Diabetic Rats

Access this Article

Author(s)

Abstract

Fasting causes gastric mucosal damage in streptozotocin(STZ)−induced diabetic rats, but its pathogenic mechanism remains to be elucidated.The aim of the present study was to investigate the alteration of gastric mucosal mucin, one of the gastric defensive factors against the developmet of such damage.Diabetes was induced in rats by intravenous injection of STZ(65 mg/kg).The experiments were performed using 4−week STZ−diabetic rats with blood glucose levels above 350 mg/dl.The amount of gastric mucus glycoprotein was determined by gel filtration, and the distribution of neutral and acidic mucins in the stomach epithelium was examined by histochemical analysis.In normal rats, 24−h fasting neither affected the gastric mucin content nor caused any macroscopic gastric mucosal injury.In contrast, starvation significantly reduced the amount of total gastric mucus glycoprotein prior to the formation of mucosal lesions in the STZ−diabetic rats.Nine hours after food deprivation, the gastric damage developed in about 70% of the diabetic rats, the amount of mucus glycoprotein markedly decreased, and both the neutral and acidic mucins diminished in the epithelium.Taken together, in STZ−diabetic rats, fasting by itself depletes gastric mucus glycoprotein, and this depletion may be involved in the pathogenic mechanism of the formation of gastric mucosal lesions.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(1), 51-55, 2000-09-01

    The Japanese Pharmacological Society

References:  19

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008185130
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5526075
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top