Cardiac Angiotensin II Receptors Are Downregulated by Chronic Angiotensin II Infusion in Rats

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Author(s)

Abstract

We studied the effect of chronic(7 days)angiotensin II infusion in a subpressor(200ng/kg per minute)dose on angiotensin II receptors in the left ventricle in rats.Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration.The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20−30% in the angiotensin II−infused left ventricular membranes without affecting the affinity.Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(1), 75-77, 2000-09-01

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008185235
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5526103
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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