Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice

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Author(s)

    • Kamei Junzo KAMEI Junzo
    • Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
    • Zushida Ko ZUSHIDA Ko
    • Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

Abstract

The antinociceptive effect of mexiletine in diabetic mice was examined.Tail−flick latencies at heat intensity of 35 and 50 V in diabetic mice were shorter than those in non−diabetic mice.In diabetic mice, mexiletine increased the tail−flick latency at 35 V to the level observed in non−diabetic mice.The tail−flick latency at 50 V in diabetic mice, but not in non−diabetic mice, was increased by pretreatment with capsaicin(0.56 nmol, i.t., 24 h).The antinociceptive effect of mexiletine in diabetic mice was reduced by capsaicin.These results suggest that the mexiletine−induced antinociception in diabetic mice involves the inhibition of the nociceptive transmission of capsaicin−sensitive primary afferent fibers.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(1), 89-92, 2000-09-01

    The Japanese Pharmacological Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008185298
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5526134
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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