The Effects of Soybean Transphosphatidylated Phosphatidylserine on Cholinergic Synaptic Functions of Mice

Access this Article

Author(s)

Abstract

The effects of soybean transphosphatidylated phosphatidylserine(SB−tPS)on cholinergic synaptic functions were investigated using cerebral cortical synaptosomes from mice.Treatment of the synaptosomes with SB−tPS increased high K<SUP>+</SUP>−induced acetylcholine(ACh)release in a bell−shaped, dose−dependent manner without affecting ACh synthesis.SB−tPS(10 and 50μM)also enhanced synaptosomal synthesis of sn−glycero−3−phosphocholine, but did not affect phosphorylcholine synthesis.In contrast, the choline synthesis was significantly reduced as SB−tPS concentration increased.The present result that SB−tPS modified the cholinergic pathway can partly explain its nootropic functions.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(1), 93-96, 2000-09-01

    The Japanese Pharmacological Society

References:  15

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008185314
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5526128
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top