The Effects of Soybean Transphosphatidylated Phosphatidylserine on Cholinergic Synaptic Functions of Mice.

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  • Yamatoya Hideyuki
    Yakult Central Institute for Microbiological Research,1796 Yaho,Kunitachi,Tokyo 186-8650,Japan
  • Sakai Masashi
    Yakult Central Institute for Microbiological Research,1796 Yaho,Kunitachi,Tokyo 186-8650,Japan
  • Kudo Satoshi
    Yakult Central Institute for Microbiological Research,1796 Yaho,Kunitachi,Tokyo 186-8650,Japan

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  • Effects of Soybean Transphosphatidylated Phosphatidylserine on Cholinergic Synaptic Functions of Mice

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Abstract

The effects of soybean transphosphatidylated phosphatidylserine(SB−tPS)on cholinergic synaptic functions were investigated using cerebral cortical synaptosomes from mice.Treatment of the synaptosomes with SB−tPS increased high K+−induced acetylcholine(ACh)release in a bell−shaped, dose−dependent manner without affecting ACh synthesis.SB−tPS(10 and 50μM)also enhanced synaptosomal synthesis of sn−glycero−3−phosphocholine, but did not affect phosphorylcholine synthesis.In contrast, the choline synthesis was significantly reduced as SB−tPS concentration increased.The present result that SB−tPS modified the cholinergic pathway can partly explain its nootropic functions.

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