SK4 Encodes Intermediate Conductance Ca^<2+>-Activated K^+ Channels in Mouse Urinary Bladder Smooth Muscle Cells

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Author(s)

    • Ohya Susumu OHYA Susumu
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • MURAKI Katsuhiko
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • WATANABE Minoru
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • IMAIZUMI Yuji
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

Abstract

The single channel current of intermediate conductance Ca<SUP>2+</SUP>−activated K<SUP>+</SUP> channel(IK channel)was measured in mouse urinary bladder myocytes(MBM), and the molecular basis of the channel was suggested to be the SK4 subtype by RT−PCR.Among Ca<SUP>2+</SUP>−activated K<SUP>+</SUP> channel subtypes(SK2, SK3, SK4 and BK), the mRNAs of SK4 and BK were predominantly expressed in MBM.IK channel currents recorded from MBM showed:38.7 pS slope conductance under symmetrical 140 mM K<SUP>+</SUP> conditions, Ca<SUP>2+</SUP>−dependent activation, and blockade by charybdotoxin and econazole.These results strongly suggest that SK4 encodes IK channels in MBM.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(1), 97-100, 2000-09-01

    The Japanese Pharmacological Society

References:  10

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008185330
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5526166
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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