Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats

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Abstract

The effect of long−term treatment with dihydropyridine calcium antagonists(amlodipine, pranidipine, nicardipine)on the periarterial nerve function was investigated in the perfused mesenteric vascular bed isolated from spontaneously hypertensive rat(SHR).Male 8−week−old SHR received amlodipine(0.01% and 0.02%)and nicardipine(0.1%)in drinking water and pranidipine(0.0035% and 0.035%)in rat chow for 7 weeks.Mean blood pressure in SHR was significantly lowered by long−term treatment with each calcium antagonist.In mesenteric vascular preparations treated with each calcium antagonist, vasoconstriction induced by periarterial nerve stimulation(PNS;4, 8 and 12 Hz)was significantly smaller than that in non−treated SHR.The PNS(8 Hz)−evoked norepinephrine(NE)overflow in the perfusate was significantly decreased by amlodipine and pranidipine treatment, whereas nicardipine−treatment significantly enhanced the overflow of NE.In preparations with active tone produced by methoxamine and guanethidine, the PNS−induced vasodilation mediated by calcitonin gene−related peptide(CGRP)−containing(CGRPergic)vasodilator nerves was not affected by these drugs.These results suggest that long−term treatment of SHR with long−acting drugs, amlodipine and pranidipine, reduces sympathetic adrenergic nerve function but calcium antagonists have no effect on CGRPergic nerve function.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(2), 156-162, 2000-10-01

    The Japanese Pharmacological Society

References:  32

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008185617
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5549268
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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