Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats.

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  • Chiba Yoshihiko
    Department of Pharmacology,School of Pharmacy,Hoshi University,2-4-41 Ebara,Shinagawa-ku,Tokyo 142-8501,Japan
  • Takada Yuka
    Department of Pharmacology,School of Pharmacy,Hoshi University,2-4-41 Ebara,Shinagawa-ku,Tokyo 142-8501,Japan
  • Sakai Hiroyasu
    Department of Pharmacology,School of Pharmacy,Hoshi University,2-4-41 Ebara,Shinagawa-ku,Tokyo 142-8501,Japan
  • Takeyama Hisao
    Department of Pharmacology,School of Pharmacy,Hoshi University,2-4-41 Ebara,Shinagawa-ku,Tokyo 142-8501,Japan
  • Misawa Miwa
    Department of Pharmacology,School of Pharmacy,Hoshi University,2-4-41 Ebara,Shinagawa-ku,Tokyo 142-8501,Japan

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抄録

Smooth muscle responsiveness of intrapulmonary small bronchi obtained from repeatedly antigen−challenged rats was compared with that from control animals to determine whether smooth muscle contractility of peripheral airways is augmented by such repeated challenge.In intact(non−permeabilized)smooth muscles of intrapulmonary bronchi, the acetylcholine(ACh)−induced contractile response was significantly augmented in the repeated challenge group, although 60−mM K+−induced contraction was within the normal level.In β−escin−permeabilized muscles, no significant difference between groups was observed in the Ca2+−induced contractile responses.Thus, augmented ACh−induced contraction of intact intrapulmonary small bronchial smooth muscle might be, at least in part, due to an enhanced ACh−mediated Ca2+−sensitizing signal.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 84 (2), 221-224, 2000

    公益社団法人 日本薬理学会

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