Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats

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Author(s)

Abstract

Smooth muscle responsiveness of intrapulmonary small bronchi obtained from repeatedly antigen−challenged rats was compared with that from control animals to determine whether smooth muscle contractility of peripheral airways is augmented by such repeated challenge.In intact(non−permeabilized)smooth muscles of intrapulmonary bronchi, the acetylcholine(ACh)−induced contractile response was significantly augmented in the repeated challenge group, although 60−mM K<SUP>+</SUP>−induced contraction was within the normal level.In β−escin−permeabilized muscles, no significant difference between groups was observed in the Ca<SUP>2+</SUP>−induced contractile responses.Thus, augmented ACh−induced contraction of intact intrapulmonary small bronchial smooth muscle might be, at least in part, due to an enhanced ACh−mediated Ca<SUP>2+</SUP>−sensitizing signal.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(2), 221-224, 2000-10-01

    The Japanese Pharmacological Society

References:  13

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008185880
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5549430
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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