Non-competitive Inhibition of Kainate-Induced Currents by Diethylstilbestrol in Acutely Isolated Mouse CA1 Hippocampal Neurons

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Author(s)

Abstract

The effect of a synthetic estrogen, diethylstilbestrol(DES), on kainate−induced currents was investigated in the hippocampal CA1 pyramidal neurons acutely dissociated from the mice using the nystatin−perforated patch−clamp recording configuration under voltage−clamp conditions.DES inhibited the current evoked by 100μM kainate in a concentration−dependent manner with a half−maximum inhibitory concentration of 8.8μM.The action of DES was voltage−independent.Since DES produced a suppression of the maximum response of the kainate concentration−response curve, the inhibition by DES of the kainate−induced current appears to be non−competitive.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(2), 225-228, 2000-10-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008185894
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5549433
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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