The Parkinsonian Models. Invertebrates to Mammals.

DOI Web Site Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献8件 参考文献49件
  • Kitamura Yoshihisa
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan
  • Shimohama Shun
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan
  • Akaike Akinori
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • Taniguchi Takashi
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan

書誌事項

タイトル別名
  • Parkinsonian Models Invertebrates to Mammals

この論文をさがす

抄録

In contrast to Alzheimer’s disease, effective therapeutic options are available for Parkinson’s disease. Therapy of dopamine replacement such as levodopa improves the symptoms of this disease, but does not inhibit neurodegeneration in the substantia nigra. Numerous studies have suggested that endogenous and environmental neurotoxins, and oxidative stress may participate in this disease, but the detailed mechanisms are still unclear. Recent genetic studies in familial Parkinson’s disease and parkinsonism show several gene mutations. This new information regarding pathogenesis offers novel prospects for therapy. To develop novel neuroprotective drugs, it is necessary to have a model for each type of parkinsonism. This review summarizes current findings regarding parkinsonian models in vertebrates and invertebrates and discusses their value.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 84 (3), 237-243, 2000

    公益社団法人 日本薬理学会

被引用文献 (8)*注記

もっと見る

参考文献 (49)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ