Effect of the Selective Adenosine A1-Receptor Antagonist KW-3902 on Tubuloglomerular Feedback in Radiocontrast-Media-Induced Nephropathy in Rats With Chronic Nitric Oxide Deficiency.
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- Yao Kozo
- Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan
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- Heyne Nils
- Department of Pharmacology, Faculty of Medicine, University of Tübingen, Wilhelmstr. 56, 72074 Tübingen, FRG
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- Osswald Hartmut
- Department of Pharmacology, Faculty of Medicine, University of Tübingen, Wilhelmstr. 56, 72074 Tübingen, FRG
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To study the possible mechanism of renoprotective effects of adenosine A1-receptor antagonist against radiocontrast media (RCM)-induced nephropathy, we investigated the effects of adenosine A1-receptor antagonist on tubuloglomerular feedback (TGF) activity prior to and following application of RCM in chronic NO-depleted rats. TGF in NO-depleted rats was significantly enhanced compared with that in normal rats. After RCM application, the enhanced TGF was continued. A selective adenosine A1-receptor antagonist, KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), inhibited the enhanced TGF. These results suggest that KW-3902 could inhibit TGF in chronic NO-depleted rats. Renoprotective effects by adenosine antagonists could be partly due to an inhibition of TGF via the blockade of the adenosine A1-receptor.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 84 (3), 347-350, 2000
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679264552448
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- NII論文ID
- 10008186391
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXosVKhsrs%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5587018
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- PubMed
- 11138737
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I5587018
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- https://api.elsevier.com/content/article/PII:S0021519819305165?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/84/3/84_3_347/_pdf
- https://search.jamas.or.jp/link/ui/2001072993
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- 本文言語コード
- en
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