Correction of Hyperglycemia and Insulin Sensitivity by T-1095, an Inhibitor of Renal Na^+-Glucose Cotransporters, in Streptozotocin-Induced Diabetic Rats

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Author(s)

Abstract

We investigated the effects of T-1095 (3-(benzo[b]furan-5-yl)-2′, 6′-dihydroxy-4′-methylpropiophenone 2′-O-(6-O-methoxycarbonyl)-β-D-glucopyranoside), an orally active inhibitor of Na<SUP>+</SUP>-glucose cotransporter, on hyperglycemia and insulin resistance in skeletal muscle of streptozotocin (STZ)-induced diabetic rats. Chronic (4 weeks) administration of T-1095 as food admixture (0.01-0.1% wt/wt) suppressed the blood glucose level without affecting the food intake and body weight. In addition, the reduced 2-deoxyglucose uptake and lactate release in the soleus muscle of STZ rat was ameliorated by chronic treatment of T-1095. These data suggest that T-1095 improves insulin sensitivity in skeletal muscle through correction of hyperglycemia and has novel therapeutic potential for treatment of diabetes mellitus through removing glucose toxicity.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(3), 351-354, 2000-11-01

    The Japanese Pharmacological Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008186407
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5587042
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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