Effect of APGW-Amide on [Ca^<2+>]_i in Rat Pheochromocytoma PC12 Cells

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抄録

In order to determine whether Ala-Pro-Gly-Try-NH<SUB>2</SUB> (APGW-amide) could affect mammalian excitable cells, we investigated the effect of APGW-amide in PC12 cells. APGW-amide caused a rapid [Ca<SUP>2+</SUP>]<SUB>i</SUB> elevation, which was completely prevented by elimination of extracellular Ca<SUP>2+</SUP> with EGTA and inhibited by two L-type Ca<SUP>2+</SUP> channel blockers. [Ca<SUP>2+</SUP>]<SUB>i</SUB> elevation was also blocked by a specific PKC inhibitor and prolonged pretreatment of cells with PMA. These results indicate that APGW-amide elevates [Ca<SUP>2+</SUP>]<SUB>i</SUB> in PC12 cells, possibly by Ca<SUP>2+</SUP> influx via L-type Ca<SUP>2+</SUP> channel activated by PKC.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(3), 355-359, 2000-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008186423
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5587071
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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