Effect of APGW-Amide on [Ca^<2+>]_i in Rat Pheochromocytoma PC12 Cells

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Author(s)

Abstract

In order to determine whether Ala-Pro-Gly-Try-NH<SUB>2</SUB> (APGW-amide) could affect mammalian excitable cells, we investigated the effect of APGW-amide in PC12 cells. APGW-amide caused a rapid [Ca<SUP>2+</SUP>]<SUB>i</SUB> elevation, which was completely prevented by elimination of extracellular Ca<SUP>2+</SUP> with EGTA and inhibited by two L-type Ca<SUP>2+</SUP> channel blockers. [Ca<SUP>2+</SUP>]<SUB>i</SUB> elevation was also blocked by a specific PKC inhibitor and prolonged pretreatment of cells with PMA. These results indicate that APGW-amide elevates [Ca<SUP>2+</SUP>]<SUB>i</SUB> in PC12 cells, possibly by Ca<SUP>2+</SUP> influx via L-type Ca<SUP>2+</SUP> channel activated by PKC.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(3), 355-359, 2000-11-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008186423
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5587071
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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