Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

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著者

    • INAIZUMI Keiichi
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • KASAJIMA Kazumi
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • KANOH Reiko
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • FUKUISHI Nobuyuki
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • AKAGI Masaaki
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

抄録

The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(3), 363-366, 2000-11-01

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008186451
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5587099
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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