Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Kappa B During Hepatic Ischemia in Rats

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Author(s)

    • INAIZUMI Keiichi
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • KASAJIMA Kazumi
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • KANOH Reiko
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • FUKUISHI Nobuyuki
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
    • AKAGI Masaaki
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

Abstract

The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(3), 363-366, 2000-11-01

    The Japanese Pharmacological Society

References:  15

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008186451
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5587099
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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