Role of 5-HT_<1A> Receptors in a Mouse Passive Avoidance Paradigm

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Author(s)

Abstract

The effect on memory processes of modulation of 5-HT<SUB>1A</SUB> receptor subtype was investigated in the mouse passive avoidance test. The administration of 5-HT<SUB>1A</SUB>-receptor antagonists NAN-190 (1-(2-methoxyphenyl)-4-[4-2-phthalimmido)butyl]piperazine) and WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide) produced a dose-dependent amnesic effect comparable to that obtained with the well-known amnesic agents scopolamine and dicyclomine. Pretreatment with the 5-HT<SUB>1A</SUB>-receptor agonists 8-OH-DPAT ((±)-8-hydroxy-dipropylaminotetralin) and 5-CT (5-carboxamidotryptamine) dose-dependently prevented the amnesia induced by 5-HT<SUB>1A</SUB> antagonists, scopolamine, dicyclomine and exposure to an hypoxic environment. The antiamnesic effect exerted by 5-HT<SUB>1A</SUB>-receptor agonists was comparable to that produced by the nootropic drug piracetam and cholinesterase inhibitor physostigmine. At effective doses, neither 5-HT<SUB>1A</SUB>-receptor agonists nor 5-HT<SUB>1A</SUB>-receptor antagonists produced any impairment of mouse motor coordination (rota-rod test), spontaneous motility (Animex apparatus) and inspection activity (hole board). These results indicate that modulation of 5-HT<SUB>1A</SUB>-receptors appears to play an important role in the regulation of cognitive processes.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(4), 418-424, 2000-12-01

    The Japanese Pharmacological Society

References:  39

Codes

  • NII Article ID (NAID)
    10008186694
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    5612040
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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