The Effects of Melatonin in Glutamate-Induced Neurotoxicity of Rat Cerebellar Granular Cell Culture

Access this Article

Author(s)

Abstract

In the present study, melatonin was tested in subsequent doses in glutamate induced neurotoxicity in cerebellar granular cell culture of rat pups. Glutamate at 10<SUP>-7</SUP>M was found to induce neuronal cell death. The dead cell score was 2.75±0.7 in the control, while it was found to be 35.12±1.8 in the glutamate-administered group (P<0.0001). Melatonin very potently blocked glutamate neurotoxicity at all doses tested, with 10<SUP>-3</SUP>M, the highest dose tested, being the most effective. Glutamate may exert a neuroprotective effect by blocking one or more steps of the oxidation cascade in neurons and this effect may be blocked by melatonin.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(4), 467-469, 2000-12-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008186913
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5612181
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
Page Top