Effect of Hydrogen Peroxide on Guinea Pig Nasal Mucosa Vasculature

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Author(s)

Abstract

The effect of hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) on guinea pig nasal mucosa vasculature was studied by in vitro assay. H<SUB>2</SUB>O<SUB>2</SUB> elicited relaxation of guinea pig nasal mucosa strips precontracted with phenylephrine in a concentration-dependent manner. The relaxant response to H<SUB>2</SUB>O<SUB>2</SUB> was abolished in the presence of catalase. Preincubation of the strips with N<SUP>G</SUP>-nitro-L-arginine methyl ester or methylene blue significantly attenuated the relaxant responses elicited by H<SUB>2</SUB>O<SUB>2</SUB>. Fluorescence caused by DAF-2 DA, a fluorescence indicator for nitric oxide, was observed along the nasal mucosa vasculature in response to H<SUB>2</SUB>O<SUB>2</SUB>. These results suggest that H<SUB>2</SUB>O<SUB>2</SUB> induced relaxation of the guinea pig nasal mucosa vasculature and that this relaxation in mediated by the NO/cGMP pathway.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(4), 470-473, 2000-12-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008186929
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    5612190
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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