Ca^<2+>-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle

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Author(s)

    • YOSHIMOTO Ryo
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
    • HORI Masatoshi
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
    • TAKAHASHI Katsuhito
    • Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • KATSUKI Motoya
    • Department of DNA Biology and Embryo Engineering, Institute for Medical Science, The University of Tokyo
    • OZAKI Hiroshi
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
    • KARAKI Hideaki
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo

Abstract

Role of h1 calponin on Ca<SUP>2+</SUP>-sensitivity of smooth muscle contraction was investigated using h1 calponin gene-deficient mice (CP−/−) and wild type mice (CP+/+). PGF<SUB>2α</SUB> induced a comparable force in intact aorta of CP+/+ and CP−/−. DPB showed similar effects to PGF<SUB>2α</SUB>. In membrane-permeabilized ileal smooth muscle, PDBu enhanced Ca<SUP>2+</SUP>-sensitivity of contraction comparably in CP+/+ and CP−/−. GTPγ-S showed similar effects. Our results suggest that h1 calponin does not regulate Ca<SUP>2+</SUP>-sensitivity in the contractile mechanism of smooth muscle.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 84(4), 474-475, 2000-12-01

    The Japanese Pharmacological Society

References:  9

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008186945
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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