Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine

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Author(s)

    • Sakai Akiko SAKAI Akiko
    • Laboratories of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • NODA Kazuhiro
    • Laboratories of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • UENO Koichi
    • Laboratories of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
    • YANO Shingo
    • Laboratories of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University

Abstract

As a way of alleviating severe constipation in cancer patients taking morphine to relieve pain, effects of <i>Dai-kenchu-to</i> (DKT), a traditional Japanese herbal medicine (<i>Kampo</i> medicine), on gastrointestinal transit in mice or on the isolated guinea pig ileum were studied in special reference to morphine. Without altering the anti-nociceptive effect of morphine, DKT was significantly effective against morphine-induced disorder of gastrointestinal transit in mice as assessed by the charcoal meal test for the intestine and measurement of transit time for the colon tract. The results of in vitro studies with guinea pig ileum suggest that abatement of morphine-induced disorder of transit by DKT is caused by both moderate contraction of morphine-treated longitudinal muscle and relaxation of morphine-induced tonic contraction of circular muscle.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 88(2), 217-221, 2002-02-01

    The Japanese Pharmacological Society

References:  14

Cited by:  10

Codes

  • NII Article ID (NAID)
    10008187346
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    6073900
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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