Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats

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Author(s)

Abstract

Traditionally, <i>Puerariae radix</i> had been used for the treatment of alcohol-related problems. In this study, effects of <i>Puerariae radix</i> on cell proliferation and nitric oxide synthase expression in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats were investigated via 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Alcohol administration was shown to inhibit the numbers of both BrdU-positive and NADPH-d-positive cells, while <i>Puerariae radix</i> treatment was shown to increase those numbers. It is possible that nitric oxide, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 88(3), 355-358, 2002-03-01

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008188105
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    6119682
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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