Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations

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Author(s)

Abstract

Chronotropic, inotropic and coronary effects of Y-27632 ((+)-(<i>R</i>)-<i>trans</i>-4-(1-aminoethyl)-<i>N</i>-(4-pyridyl) cyclohexanecarboxamide dihydrochloride, monohydrate), a specific inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK), were assessed using canine isolated, blood-perfused heart preparations. Y-27632 slightly enhanced sinoatrial automaticity and significantly increased coronary blood flow, while it decreased ventricular contraction. The concentrations of Y-27632 needed to cause the currently observed changes were similar to those inhibiting ROCK in a previous in vitro study. These results suggest that the constitutional ROCK in the heart mainly regulates the ventricular contractility and coronary vascular tone rather than the sinoatrial automaticity.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 88(3), 359-361, 2002-03-01

    The Japanese Pharmacological Society

Codes

  • NII Article ID (NAID)
    10008188121
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    6119700
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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