Failure of the Oxytocin-Induced Increase in Secretion of Urinary Kallikrein in Young Spontaneously Hypertensive Rats

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Author(s)

    • ADACHI Keiichi
    • Department of Pharmacology, Kitasato University School of Medicine
    • OHNO Takashi
    • Department of Pharmacology, Kitasato University School of Medicine
    • OGINO Michiko
    • Department of Pharmacology, Kitasato University School of Medicine
    • SAITO Maki
    • Department of Pharmacology, Kitasato University School of Medicine
    • KIZUKI Kazuyuki
    • Department of Biochemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo
    • KATORI Makoto
    • Department of Pharmacology, Kitasato University School of Medicine

Abstract

Urinary kallikrein excretion during oxytocin (OT) infusion were studied in anesthetized (sodium pentobarbital, 50 mg/kg, i.p.) young (4-weeks-old) spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). OT-infusion (30 nmol/kg/30 min) to WKY significantly increased urinary excretion of the active kallikrein from the basal levels (25.4±5.6 10<SUP>-2</SUP> × AU/15 min, n=5) to 37.3±5.0 10<SUP>-2</SUP> × AU/ 15 min (P<0.05, n=5) and 50.7±17.1 10<SUP>-2</SUP>× AU/15 min (P<0.05, n=5) 15 and 30 min after the start of OT-infusion, respectively. In SHR, OT-infusion did not increase the urinary excretion of active kallikrein, but did decrease the urine volume and sodium excretion. The concentration of the active kallikrein in the kidney of WKY was not changed by OT-infusion, but that of SHR was slightly increased. The OTinfusion resulted in significantly higher concentrations of the active kallikrein in SHR kidney than in WKY kidney. These results suggest that less excretion of urinary kallikrein in SHR during OT-infusion may be attributable to a lower response in the secretion of kallikrein from the kidney.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(1), 11-19, 1996-05

    The Japanese Pharmacological Society

References:  37

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008188162
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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