Potentiation of _L-Dopa-Induced Behavioral Excitement by Histamine H_1-Receptor Antagonists in Mice
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Effects of histamine H<SUB>1</SUB>-receptor antagonists on L-dopa-induced behavioral excitement were examined in mice to confirm behaviorally the inhibition of dopamine uptake by these compounds. L-Dopa (100-300 mg/kg, s.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a dose-dependent behavioral excitement. The marked excitement induced by L-dopa (300 mg/kg) plus pargyline was significantly inhibited by pimozide (0.1-1 mg/kg, s.c.), a selective dopamine antagonist. Tripelennamine (10 mg/kg, s.c.), <I>d</I>-chlorpheniramine (1 and 2 mg/kg, s.c.), homochlorcyclizine (2 and 5 mg/kg, s.c.), diphenhydramine (2 and 5 mg/kg, s.c.) and mepyramine (2 and 5 mg/kg, s.c.) each markedly enhanced the moderate behavioral excitement induced by L-dopa (150 mg/kg) plus pargyline. These findings are behavioral evidence for inhibition of dopamine uptake by H<SUB>1</SUB> antagonists, which has been suggested by neurochemical studies.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 71(1), 81-84, 1996-05
The Japanese Pharmacological Society