Potentiation of _L-Dopa-Induced Behavioral Excitement by Histamine H_1-Receptor Antagonists in Mice

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Author(s)

    • SATO Tomoaki
    • Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University
    • HAMAOKA Sumiko
    • Department of Hospital Pharmacy, Okayama University Medical School
    • GOMITA Yutaka
    • Department of Hospital Pharmacy, Okayama University Medical School
    • OISHI Ryozo
    • Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University

Abstract

Effects of histamine H<SUB>1</SUB>-receptor antagonists on L-dopa-induced behavioral excitement were examined in mice to confirm behaviorally the inhibition of dopamine uptake by these compounds. L-Dopa (100-300 mg/kg, s.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a dose-dependent behavioral excitement. The marked excitement induced by L-dopa (300 mg/kg) plus pargyline was significantly inhibited by pimozide (0.1-1 mg/kg, s.c.), a selective dopamine antagonist. Tripelennamine (10 mg/kg, s.c.), <I>d</I>-chlorpheniramine (1 and 2 mg/kg, s.c.), homochlorcyclizine (2 and 5 mg/kg, s.c.), diphenhydramine (2 and 5 mg/kg, s.c.) and mepyramine (2 and 5 mg/kg, s.c.) each markedly enhanced the moderate behavioral excitement induced by L-dopa (150 mg/kg) plus pargyline. These findings are behavioral evidence for inhibition of dopamine uptake by H<SUB>1</SUB> antagonists, which has been suggested by neurochemical studies.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(1), 81-84, 1996-05

    The Japanese Pharmacological Society

References:  12

Codes

  • NII Article ID (NAID)
    10008188398
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • Data Source
    CJP  J-STAGE 
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