Prostanoid Receptor-Mediated Calcium Signaling in Cultured Rat Astrocytes.

• Kitanaka Junichi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University

• Takuma Kazuhiro

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University

• Kondo Kaoru

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University

• Baba Akemichi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University

抄録

We investigated prostanoid-induced intracellular Ca²⁺ mobilization in Ca²⁺-sensitive dye fura-2-loaded cultured astrocytes. The thromboxane (TX) A₂ analog STA₂ (9, 11-epithio-11, 12-methanoTXA₂) and/or prostaglandin (PG) F_2α (each used at 1 μM) stimulated intracellular Ca²⁺ mobilization in single cultured rat type 1 astrocytes. Three response patterns were observed: only STA₂-sensitive, only PGF_2α-sensitive, and both prostanoids-sensitive cells. The Ca²⁺ response was prostanoid-dose-dependent (0.1-1 μM) and showed a rapid spike-like Ca²⁺ rise that peaked within 30 sec after the stimulation by the ligand. These observations suggest that type 1 astrocytes are heterogeneous with respect to the expression of receptors for TXA₂ and PGF_2α, which are linked to Ca²⁺ mobilization.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 71 (1), 85-87, 1996

  公益社団法人 日本薬理学会

キーワード

• Thromboxane A<SUB>2</SUB>
• Ca<SUP>2+</SUP> mobilization
• Astrocyte

詳細情報

• CRID: 1390001204287887488
• NII論文ID: 10008188411
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.71.85
• COI: 1:CAS:528:DyaK28XjtF2msbw%3D
• ISSN: 13473506
• ISSN: 00215198
• PubMed: 8791175
• Web Site: https://api.elsevier.com/content/article/PII:S002151981935317X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S002151981935317X?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1996199911
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可