The Role of Histamine H_1-Receptors in the Anticonvulsive Effect of Morphine against Maximal Electroconvulsive Shock in Mice

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Author(s)

    • ULUGOL Ahmet
    • Department of Pharmacology, Faculty of Medicine, Trakya University
    • DOKMECI Dikmen
    • Department of Pharmacology, Faculty of Medicine, Trakya University
    • DOKMECI Ismet
    • Department of Pharmacology, Faculty of Medicine, Trakya University

Abstract

Morphine is known to release histamine from mast cells. It is also known that histamine receptors mediate some of morphine''s effects on the central nervous system. The contribution of H<SUB>1</SUB>-and H<SUB>2</SUB>-receptors to the effect of morphine on maximal electroconvulsive shock in mice was investigated in the present experiments. Morphine showed a dose-dependent anticonvulsive effect, but produced spontaneous clonic convulsions at higher doses (100 mg/kg, i.p.). The anticonvulsive effect of morphine (1 mg/kg, i.p.) was antagonized by histamine H<SUB>1</SUB>-receptor antagonists, dimethindene (0.1 mg/kg, i.p.), promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p.), but not by the H<SUB>2</SUB>-receptor antagonist ranitidine (10-50 μg, i.c.v.). These results show that morphine has an anticonvulsive effect via histamine H<SUB>1</SUB>-receptors against maximal electroconvulsive shock in mice.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(2), 109-112, 1996-06

    The Japanese Pharmacological Society

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008188499
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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