Influence of Cholesterol Feeding on Bile Acid Metabolism in Young and Aged Germ-Free Rats

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Abstract

The effects of cholesterol feeding on serum and liver cholesterol levels, fecal and biliary bile acid levels, bile acid pool size and bile acid composition were examined in 2-, 12- and 24-month-old male germ-free rats. The major bile acids in these animals were cholic and β-muricholic acids. Cholesterol feeding increased synthesis of bile acids by 3- to 4-fold, especially that of chenodeoxycholic acid (mainly β-muricholic acid in the rat), decreasing the cholic acid/chenodeoxycholic acid (CA/CDCA) ratio in all rats regardless of age, even though the CA/CDCA ratio increased as a linear function of age in both diet groups. Cholesterol feeding increased the serum cholesterol level markedly in aged rats. This hypercholesterolemia may be produced by the increase in CA/CDCA ratio in aged rats.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(2), 113-118, 1996-06

    The Japanese Pharmacological Society

References:  22

Codes

  • NII Article ID (NAID)
    10008188521
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • Data Source
    CJP  J-STAGE 
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