3-Hydroxykynurenine Toxicity on the Rat Striatum In Vivo

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Author(s)

    • NAKAGAMI Yasuhiro
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
    • SAITO Hiroshi
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
    • KATSUKI Hiroshi
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

Abstract

3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is elevated under several pathological states including Huntington''s disease. In the present study, we examined the possible toxicity of 3-HK by injection of this substance into rat brain. Intrastriatal injection of 3-HK (50 nmol) induced tissue damage around the injected site. Quinolinic acid (QA) at 200 nmol also induced tissue damage, which was comparable in size to that induced by 50 nmol 3-HK. Co-administration of MK-801 significantly reduced QA-induced lesion, but failed to prevent 3-HK-induced lesion. On the other hand, the antioxidant <I>N</I>-acetyl-<SUB>L</SUB>-cysteine (10 nmol) reduced 3-HK-induced damage. Thus, 3-HK may be involved in brain pathogenesis by providing oxygen radicals.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(2), 183-186, 1996-06

    The Japanese Pharmacological Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008188738
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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