Nitric Oxide but Not Carbon Monoxide Is Involved in Spatial Learning of Mice.

DOI Web Site Web Site PubMed 被引用文献2件 参考文献41件
  • Toyoda Miwa
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
  • Saito Hiroshi
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
  • Matsuki Norio
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

この論文をさがす

抄録

The aim of the present study was to elucidate the role of carbon monoxide (CO) in learning and to compare it with that of nitric oxide (NO). Effects of an inhibitor of heme oxygenase which produces CO, Zn-protoporphyrin IX, on passive avoidance learning and spatial learning in mice were examined using step through, step down and water maze tests. Zn-protoporphyrin IX (10, 20 nmol, i.c.v.) affected neither type of learning. In contrast, N-ω-nitro-L-arginine (40 nmol, i.c.v.), an inhibitor of NO synthase, impaired spatial learning, but not passive avoidance learning. These results suggest that NO but not CO is involved in spatial learning.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 71 (3), 205-211, 1996

    公益社団法人 日本薬理学会

被引用文献 (2)*注記

もっと見る

参考文献 (41)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ