Nitric Oxide but Not Carbon Monoxide Is Involved in Spatial Learning of Mice

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Author(s)

    • TOYODA Miwa
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
    • SAITO Hiroshi
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
    • MATSUKI Norio
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

Abstract

The aim of the present study was to elucidate the role of carbon monoxide (CO) in learning and to compare it with that of nitric oxide (NO). Effects of an inhibitor of heme oxygenase which produces CO, Zn-protoporphyrin IX, on passive avoidance learning and spatial learning in mice were examined using step through, step down and water maze tests. Zn-protoporphyrin IX (10, 20 nmol, i.c.v.) affected neither type of learning. In contrast, <I>N</I>-ω-nitro-L-arginine (40 nmol, i.c.v.), an inhibitor of NO synthase, impaired spatial learning, but not passive avoidance learning. These results suggest that NO but not CO is involved in spatial learning.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(3), 205-211, 1996-07

    The Japanese Pharmacological Society

References:  23

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008188894
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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