Characteristic Upregulation of Dopamine D_1-Receptor in Rat Striatum after 6-Hydroxydopamine Treatment

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Author(s)

    • IWATA Shin-ichi
    • Department of Pharmacology, Faculty of Medicine, University of Kagoshima
    • SHIMIZU Takao
    • Department of Pharmacology, Faculty of Medicine, University of Kagoshima
    • NOMOTO Masahiro
    • Department of Pharmacology, Faculty of Medicine, University of Kagoshima
    • FUKUDA Takeo
    • Department of Pharmacology, Faculty of Medicine, University of Kagoshima

Abstract

We measured the number of D<SUB>1</SUB>-receptors (B<SUB>max</SUB>) in the striatum whose dopaminergic terminals were destroyed to various degrees by 6-hydroxydopamine (6-OHDA) to clarify the relationship between the degree of denervation and the change in B<SUB>max</SUB> for D<SUB>1</SUB>-receptor. Rats were sacrificed 28 days after 6-OHDA treatment, and [<SUP>3</SUP>H]SCH23390 (R(+)-7-chloro-8-hydroxy-3-methyl-l-phenyl-2, 3, 4, 5-tetrahydro-1<I>H</I>-3-benzazepine) binding capacity and monoamine content were measured in striatal homogenate. B<SUB>max</SUB> was significantly upregulated when dopamine content was reduced to less than 5% of that in the vehicletreated striatum. In contrast, it was significantly decreased when dopamine content was 5—25% of that in the vehicle-treated striatum. The D<SUB>1</SUB>-receptors showed either upregulation or downregulation depending on the degree of denervation.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(3), 255-258, 1996-07

    The Japanese Pharmacological Society

References:  14

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008189079
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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