Effect of Fluvoxamine on 5-Hydroxytryptamine Uptake, Paroxetine Binding Sites and Ketanserin Binding Sites in the Japanese Monkey Brain and Platelets, In Vivo and In Vitro

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Abstract

We investigated the in vitro effects of fluvoxamine on <SUP>3</SUP>H-paroxetine binding and <SUP>3</SUP>H-monoamine uptake in monkey cerebral cortex in comparison with those of other antidepressants. Fluvoxamine selectively inhibited <SUP>3</SUP>H-5-hydroxytryptamine (5-HT) uptake and <SUP>3</SUP>H-paroxetine binding. However, it did not alter <SUP>3</SUP>H-norepinephrine or <SUP>3</SUP>H-dopamine uptake. In addition, we examined the effects of chronic treatment with fluvoxamine (5 mg/kg per day, p.o.) on 5-HT uptake sites that bind <SUP>3</SUP>H-paroxetine and 5-HT<SUB>2</SUB> receptors that bind <SUP>3</SUP>H-ketanserin, in monkey brains and platelets. Chronic treatment with fluvoxamine affected neither the paroxetine binding sites nor the kentanserin binding sites of the brains and platelets. These results suggest that long-term treatment with fluvoxamine does not affect either the 5-HT uptake sites or 5-HT<SUB>2</SUB>-receptors of 5-HT neurons in monkey brain in spite of its strong inhibitory effect on 5-HT uptake in vitro.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(4), 291-298, 1996-08-01

    The Japanese Pharmacological Society

References:  42

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008189209
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
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