The Possible Involvement of GABA_A Systems in the Antinarcotic Effect of Majonoside-R2, a Major Constituent of Vietnamese Ginseng, in Mice

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著者

    • HUONG Nguyen Thi Thu
    • Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
    • MATSUMOTO Kinzo
    • Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
    • YAMASAKI Kazuo
    • Department of Biological Active Substances, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
    • DUC Nguyen Minh
    • The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh University of Medicine and Pharmacy
    • NHAM Nguyen Thoi
    • The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh University of Medicine and Pharmacy
    • WATANABE Hiroshi
    • Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

抄録

The effect of majonoside-R2 on morphine and U-50, 488H-induced antinociception was examined by the tail-pinch test in mice and compared with that of diazepam. Majonoside-R2 and diazepam inhibited the morphine and U-50, 488H-induced antinociception, and the actions were antagonized by the benzodiazepine receptor antagonist flumazenil and the GABA-gated Cl<SUP>-</SUP> channel blocker picrotoxin. Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABA<SUB>A</SUB> antagonists bicuculline and picrotoxin. These results indicate that GABA<SUB>A</SUB> systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(4), 345-349, 1996-08-01

    The Japanese Pharmacological Society

参考文献:  12件中 1-12件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008189387
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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