The Possible Involvement of GABA_A Systems in the Antinarcotic Effect of Majonoside-R2, a Major Constituent of Vietnamese Ginseng, in Mice

Access this Article

Search this Article

Author(s)

    • HUONG Nguyen Thi Thu
    • Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
    • MATSUMOTO Kinzo
    • Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
    • YAMASAKI Kazuo
    • Department of Biological Active Substances, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
    • DUC Nguyen Minh
    • The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh University of Medicine and Pharmacy
    • NHAM Nguyen Thoi
    • The Science-Production Centre of Vietnamese Ginseng, Ho Chi Minh University of Medicine and Pharmacy
    • WATANABE Hiroshi
    • Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

Abstract

The effect of majonoside-R2 on morphine and U-50, 488H-induced antinociception was examined by the tail-pinch test in mice and compared with that of diazepam. Majonoside-R2 and diazepam inhibited the morphine and U-50, 488H-induced antinociception, and the actions were antagonized by the benzodiazepine receptor antagonist flumazenil and the GABA-gated Cl<SUP>-</SUP> channel blocker picrotoxin. Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABA<SUB>A</SUB> antagonists bicuculline and picrotoxin. These results indicate that GABA<SUB>A</SUB> systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(4), 345-349, 1996-08-01

    The Japanese Pharmacological Society

References:  12

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008189387
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • Data Source
    CJP  CJPref  J-STAGE 
Page Top